ncRNA name | hsa-miR-513a-5p |
ncRNA Category | miRNA |
Disease name | retinoblastoma (RB) |
Species | Homo sapiens |
Tissues/Cell_line | RB cell line Y79 |
Methods | RT-PCR, qPCR, flow cytometry, transfection, luciferase reporter assay |
Expression pattern | down-regulated |
Functional description | Etoposide can promote B7-H1 expression in Rb cells, which may be associated with chemoresistance. miR-513a-5p inhibits the mRNA and protein expression of B7-H1 via binding to the 3'-UTR of B7-H1 mRNA. |
PubMed ID | 22886978 |
Year | 2012 |
Title | Effect of miR-513a-5p on etoposide-stimulating B7-H1 expression in retinoblastoma cells. |
Drug-related ncRNA | YES (Etoposide) |
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